FRIDAY, JUNE 22, 2018

Vaccine created to fight Ebola, rabies

Using a reverse genetics system and the currently available rabies vaccine, researchers of Thomas Jefferson University in Philadelphia have created vaccines that induced humoral immunity against both Ebola and rabies.
Lead researcher Matthias Schnell and his colleagues created the vaccines, which contain either a chemically inactivated or live rabies virus that expressed the Zaire ebolavirus glycoprotein, Med Page Today reports. The mice that were inoculated with the vaccine candidates survived lethal challenges with both viruses.
While other successful Ebola vaccine candidates have been identified, none of them have been brought to market.
"Rabies still poses a health threat for people worldwide, and is especially devastating in developing nations where a post-exposure treatment is often not available," Schnell said, according to Med Page Today. "And Ebola still exists in parts of Central Africa and is also a chief bioterrorism concern worldwide. You can protect these people from two very lethal diseases in an area where they don't have the best access to medical care."
The study's findings were reported in the Journal of Virology.
According to the Centers for Disease Control, the Ebola virus causes Ebola hemorrhagic fever, which is a severe, often-fatal disease in humans and nonhuman primates. Rabies is a preventable viral disease in mammals that is most often transmitted through a rabid animal's bite. The rabies virus infects the nervous system, which ultimately causes disease in the brain and death.