SATURDAY, NOVEMBER 25, 2017

Pre-exposure to H1N1 may protect against H5N1

A recent study has revealed that pre-exposure to the H1N1 influenza virus, or a single dose of DNA vaccine encoding H5N1 influenza proteins, can be useful in protecting the human body from H5N1 influenza virus infection.

The highly pathogenic H5N1 avian influenza virus has a high fatality and infection rate, causing it to have a high pandemic potential. The study was seeking to see what factors may or may not affect its pathogenic potential, according to 7th Space.

In the new study, before being exposed to H5N1, mice were intranasally infected with seasonal H1N1. Six weeks later, a portion of the same mice were immunized with plasmid DNA expressing H5N1 virus NP or M1, or with a combination of the two plasmids.

Six weeks after this second exposure, the mice were challenged with a lethal dose of the H5N1 influenza virus. The protective effect of pre-exposure was then measured by the mice’s survival rate, body weight loss and the presence of residue virus titer in the lungs.

The scientists found that pre-exposure to H1N1 provided partial protection against H5N1 and a single dose injection with plasmid DNA expressing H5N1 virus NP or M1, or with a combination of the two plasmids, provided significant protection against H5N1 exposure.