In a newly published clinical trial, patients with metastatic prostate cancer who received a vaccine of harmless poxviruses engineered to spur an immune system attack on prostate tumor cells lived substantially longer than patients who received a placebo vaccine, report researchers at Dana-Farber Cancer Institute and affiliated organizations, ScienceDaily reported Jan. 26.
The findings will be published by the Journal of Clinical Oncology on its Web site and later in a print edition.
The randomized phase II study involved the PROSTVAC-VF vaccine, a combination of two weakened poxviruses that have been genetically programmed to produce slightly irregular versions of prostate specific antigen (PSA) — a protein on the surface of prostate cells that is abnormal in many prostate cancers — and three costimulatory molecules that spur the immune system to a more vigorous attack on tumor cells. The double-blinded trial included 125 patients with metastatic prostate cancer who did not respond to standard, hormone-lowering therapy. Eighty-two of the participants received the vaccine, produced by BN ImmunoTherapeutics Inc. of Mountain View, Calif., and 40 received a placebo.
At the three-year point after the study, 30 percent of the PROSTVAC-VF patients were alive, versus 17 percent of the control group. The median survival of the vaccine group was 24.5 months, compared to 16 months for the control group, an 8.5-month increase. Patients tolerated the vaccine well; only a small number experienced side effects such as fatigue, fevers, and nausea.
"Although this study is relatively small, it offers encouraging evidence of a clinically meaningful benefit from this vaccine approach," said Philip Kantoff, principal investigator and lead author from Dana-Farber. He helped design the trial.
Investigators are planning a phase III trial that will enroll about 600 patients to further evaluate the vaccine's effectiveness.
Funding from the National Cancer Institute supported the study.