Booster doses can increase response in older adults againt pertussis

Just one booster dose helped adults ages 55 and older respond well to a series of antigens that included diphtheria, tetanus and pertussis, Doctor's Guide Channels reports.

The study on the reduced antigen content DTaP vaccine was presented earlier this month by Dr. Pierre Van Damme with the Centre for the Evaluation of Vaccination of the University of Antwerp in Belgium, the website reports. It was presented as part of the 28th-annual meeting of the European Society for Pediatric Infectious Diseases.

Doctor's Guide Channels reports that the study, came as part of a subanalysis of four European clinical trials, involved the vaccination of 293 adults who received either the DTaP vaccine or a DTaP vaccine that included polio antigens. The report states that the study determined that a dose of either of the two vaccines showed a good immunological response to all diphtheria, tetanus, and pertussis antigens in adults.

In 892 percent of those studied, a booster response for pertussis antigens was observed. A 95.8 percent booster response for filamentous haemagglutinin and a 94.5 percent booster response for pertactin were also observed.

The vaccines were also found to be immunogenic for diphtheria and tetanus toxoids in the older adults.

The study was funded by GlaxoSmithKline, according to Doctor's Guide Channels.