Norovirus candidate vaccine provokes broad immune response

Norovirus candidate vaccine provokes broad immune response | Courtesy of
A new multivalent candidate vaccine has induced a broad antibody response to a number of strains of norovirus, even strains that were not included in the new vaccine or encountered by the subjects before the study.

The positive results of the study show that there may be a norovirus vaccine in the future. Typically noroviruses are elusive to the body’s natural immune system because the virus escapes using antigenic drift.

Researchers’ most recent efforts in creating a vaccine for norovirus have used virus-like particles (VLPs) built from molecules taken from the outer shell, or capsid, of the virus.

“These data reveal new information about complex norovirus immune responses to both natural exposure and to vaccination, and support the potential feasibility of an efficacious multivalent norovirus VLP vaccine for future use in human populations,” study leaders Lisa Lindesmith and Ralph Baric from the University of North Carolina said.

Experts estimate that noroviruses result in one out of every five cases of viral gastroenteritis. Approximately 300 million cases of norovirus are confirmed each year, amounting to approximately 260,000 deaths. The majority of these cases and deaths take place in countries with low incomes.

More information can be found in PLOS Medicine.

Organizations in this story

PLOS Medicine 1160 Battery St San Francisco, CA - 94111

Get notified the next time we write about PLOS Medicine!