The Health and Family Planning Commission of Guangdong Province notified Hong Kong's Department of Health’s Centre for Health Protection of another avian influenza (AH5N6) case on Tuesday.
The newest patient, a 58-year-old male, is in critical condition in a Guangzhou hospital.
China's health department has a number of measures in place to help stop the spread of the disease, including boundary control points for travelers using thermal imaging system to check body temperatures.
Posters warning people of the virus are on display at travel points. Health messages also are being broadcasted throughout arrival and departure halls.
If travelers experience any sign of respiratory illness or fever, they should don a mask, seek medical assistance and discuss their travel history with their doctor.
"All novel influenza A infections (including H5N6) are notifiable diseases in Hong Kong," a spokesman for the health department said. "Locally, we will remain vigilant and work closely with the World Health Organization and relevant health authorities to monitor the latest developments.”
The health department is urging the public to take precautions against the virus, including avoiding areas affected by the avian influenza.
"In view of cases confirmed on the mainland, members of the public should maintain good personal, food and environmental hygiene at all times during travel," the health department spokesman said.