The conjugate pneumococcal vaccine (PCV) has been a staple in the Danish childhood vaccination regimen since Oct. 1, 2007 and over the past seven-plus years, invasive pneumococcal disease (IPD) has decreased.
A seven-valent vaccine (PCV-7) was introduced on Oct. 1, 2007, while a 13-valent vaccine (PCV-13) was produced and introduced by mid-April 2010.
The total IPD incidence in the population from 2000 to 2007 was 20 cases per 100,000, and since the PCV was brought aboard in 2007 the incidence has fallen 20 percent to 988 annual cases in the PCV-7 period and even fewer with 869 annual cases in the PCV-13 period.
A recent study shows the decrease in the IPD incidence was present in both vaccinated and unvaccinated children. The most prevalent decrease was observed in children under two years of age whose incidence decreased by about 71 percent in the PCV-13 period compared with the period prior to the vaccine being introduced. This statistic can be looked at as the PCV-13 vaccine's efficacy at the population level.
The coverage of the PCV vaccines in the childhood vaccination program for birth taking place from 2007 to 2012 was in the 83- to 92-percent range for the first PCV, 80 to 92 percent for the second PCV time frame and 79 to 90 percent for the third PCV.